concept

UNFOLDED PROTEIN RESPONSE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UNFOLDED PROTEIN RESPONSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1129Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

UNFOLDED PROTEIN RESPONSE is a concept in neurodegeneration research. Key relationships include: co discussed, causes, activates. Associated with FRONTOTEMPORAL. Connected to 14 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	UNFOLDED PROTEIN RESPONSE
Key Genes/Proteins	APP, BRD4, GBA
Related Diseases	ENDOPLASMIC RETICULUM STRESS, ER STRESS, MITOCHONDRIAL DYSFUNCTION, AGING, NEURODEGENERATION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    UNFOLDED_PROTEIN_RESPONSE["UNFOLDED PROTEIN RESPONSE"]
    UNFOLDED_PROTEIN_RESPONSE -->|"regulates"| ER_homeostasis["ER homeostasis"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Mtor["Mtor"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Apoptosis["Apoptosis"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Autophagy["Autophagy"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    SPHK1["SPHK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    TARDBP["TARDBP"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    PINK1["PINK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    LC3["LC3"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    MTOR["MTOR"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    PTEN["PTEN"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    VCP["VCP"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    TBK1["TBK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE

Outgoing (146)

Target	Relation	Type	Str
APP	produces	gene	0.65
ASTROCYTES	phosphorylates	cell_type	0.65
ASTROCYTES	regulates	cell_type	0.65
ASTROCYTES	produces	cell_type	0.65
ER STRESS	regulates	phenotype	0.65
NEURONS	causes	cell_type	0.65
MITOCHONDRIAL DYSFUNCTION	interacts_with	phenotype	0.65
AGING	regulates	phenotype	0.65
NEURODEGENERATION	protects_against	disease	0.65
PROTEOSTASIS	implicated_in	phenotype	0.60
VCP	co_discussed	entity	0.50
RAPAMYCIN	activates	drug	0.50
ER STRESS	associated_with	process	0.50
ER STRESS	activates	process	0.50
PROTEOSTASIS	associated_with	phenotype	0.50
APC	associated_with	gene	0.50
NICOTINAMIDE	associated_with	drug	0.50
ISCHEMIA	associated_with	disease	0.50
LEUKEMIA	associated_with	disease	0.50
BRD4	associated_with	gene	0.50
TDP-43	associated_with	gene	0.45
NEURON	associated_with	cell_type	0.45
PINK1	associated_with	gene	0.45
TBK1	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
PTEN	associated_with	gene	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
PROTEIN AGGREGATION	associated_with	phenotype	0.45
APOE	associated_with	gene	0.45
ASTROCYTE	associated_with	cell_type	0.45
RAPAMYCIN	associated_with	drug	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
UBIQUITIN	associated_with	protein	0.45
DEMENTIA	associated_with	disease	0.45
TARDBP	associated_with	gene	0.45
VCP	associated_with	gene	0.45
TH	associated_with	gene	0.45
INFLAMMATION	associated_with	phenotype	0.45
PARKIN	associated_with	gene	0.45
DRP1	associated_with	gene	0.45
OPA1	associated_with	gene	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45
METFORMIN	associated_with	drug	0.45
AMPK	associated_with	gene	0.45
OLIGODENDROCYTES	associated_with	cell_type	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45
GBA	associated_with	gene	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
CLU	associated_with	gene	0.45
TYROBP	associated_with	gene	0.45

Incoming (983)

Source	Relation	Type	Str
ENDOPLASMIC RETICULUM STRESS	activates	phenotype	0.70
NICOTINAMIDE	activates	drug	0.70
BRD4	inhibits	gene	0.65
BRD4	regulates	gene	0.65
METFORMIN	protects_against	drug	0.65
GBA	causes	gene	0.65
MULTIPLE SCLEROSIS	causes	disease	0.65
CLU	causes	gene	0.65
TYROBP	causes	gene	0.65
OPTN	causes	gene	0.65
PRION DISEASE	produces	disease	0.65
PRION DISEASE	causes	disease	0.65
TARDBP	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
TFEB	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
APOPTOSIS	co_discussed	entity	0.50
ER STRESS	co_discussed	entity	0.50
TDP-43	activates	gene	0.50
RAPAMYCIN	activates	drug	0.50
STEM CELLS	activates	cell_type	0.50
AUTOPHAGY	inhibits	process	0.50
MTOR	activates	gene	0.50
PI3K	activates	gene	0.50
NLRP3	activates	gene	0.50
LC3	activates	gene	0.50
CANCER	activates	disease	0.50
AUTOPHAGY	activates	process	0.50
PINK1	activates	gene	0.50
TFEB	activates	gene	0.50
ALS	activates	disease	0.50
DEMENTIA	activates	disease	0.50
FRONTOTEMPORAL DEMENTIA	activates	disease	0.50
FTD	activates	disease	0.50
NEUROINFLAMMATION	activates	process	0.50
NEURODEGENERATION	associated_with	process	0.50
APOPTOSIS	activates	process	0.50
RAPAMYCIN	associated_with	drug	0.45
OXIDATIVE PHOSPHORYLATION	associated_with	phenotype	0.45
NEURON	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40
ALS	co_discussed	disease	0.40
RELA	co_discussed	gene	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
MYOT	co_discussed	gene	0.40
LATE	co_discussed	disease	0.40
ATG	co_discussed	gene	0.40
CHMP2B	co_discussed	gene	0.40
FTD	co_discussed	disease	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

UNFOLDED PROTEIN RESPONSE

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Novel Therapy Index

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Neuroresilience Mechanisms and Evidence

Frontotemporal Dementia (FTD) Mechanistic Pathway

Mitochondrial Quality Control

Synucleinopathy Mechanism

Oligodendrocytes

APOC4 — Apolipoprotein C-IV

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

ftd-tdp-pathology

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

GBA Pathway in Parkinson's Disease

Mitochondrial Dysfunction in Neurodegeneration

prion-disease

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease